NAD+ Firming Serum · Reader favorite
It holds a 4.9-star average across 117 reviews, and women over 50 keep coming back for another bottle. Here are the seven reasons this serum has everyone talking. Number four is the one most people don’t expect.
The short answer
NAD+ Firming Serum is built for skin that looks tired, thinner and less firm after 50. It tells you exactly how much NAD+ is inside (2,500 ppm), pairs it with NMN and ATP, and sits in a fragrance-free barrier base, so it firms the look of skin without the sting. In a 4-week trial, 93% of participants saw firmer-looking skin, and no irritation was reported.
01It targets the tired look at its source
If your skin looks more tired than you feel, energy is part of the story. NAD+ is the coenzyme your cells use to turn fuel into energy and to run their daily repair work. When researchers measured it in 49 human skin samples from people aged 15 to 77, NAD+ levels fell with age, in women and men alike.1 Reviews of the field link that decline to several hallmarks of aging.2
Most firming creams work on the surface. NAD+ Firming Serum is built around the cells’ energy supply, so it supports the work they do to keep skin looking firm, even and rested.
02It tells you exactly how much NAD+ is inside
Plenty of serums put NAD+ on the front of the box, then bury it in a “complex” with no number. You have no way to know if there is enough to matter.
We print it: 2,500 ppm of NAD+, right on the label. No guessing, no proprietary blend. If you like to know what you are putting on your skin, this is where trust starts.
See the full formula03It feeds the whole energy pathway
NAD+ is a big molecule, about 663 daltons. Ingredients pass the skin barrier most easily when they are under roughly 500 daltons, which makes NAD+ hard to deliver on its own.3 So the serum doesn’t rely on one ingredient. It brings in smaller partners from the same pathway.
| Ingredient | Size | Its job in the formula |
|---|---|---|
| NAD+ | About 663 daltons | The coenzyme cells use for energy and repair |
| NMN | About 334 daltons | A smaller building block of NAD+, easier to deliver |
| ATP | About 507 daltons | The energy currency cells spend every second |
Together they support the whole energy chain, not just a single step, which is why tired-looking skin can look more rested and more radiant.
04The surprise: it’s gentle
Most people expect a firming serum to tingle, peel or make skin red for a while before it gets better. This one doesn’t.
Reason #4
Zero irritation reported. In our 4-week trial, participants reported no purging, no peeling and no sun sensitivity. The formula is fragrance-free and ethanol-free, made for mature, sensitive skin that reacts to everything.
That gentleness is also why it layers so easily. It fits under moisturizer and makeup, and it works alongside retinal in a night routine.
05It firms without stripping your barrier
Older skin repairs its moisture barrier more slowly after it is disrupted.4 That is why harsh “firming” products often leave mature skin tight and uncomfortable. NAD+ Firming Serum sits in a barrier complex of the three lipids that hold the skin barrier together:
- Ceramide NPThe main structural lipid of the barrier. It helps skin hold on to water.
- CholesterolWorks with ceramides to keep the barrier flexible and sealed.
- Linoleic acidAn essential fatty acid that helps dry, mature skin feel comfortable again.
The result: skin looks firmer and feels softer and more cushioned, not stripped.
06You can see a difference in 4 weeks
of participants saw firmer-looking skin after 4 weeks, with softer-looking fine lines and smoother-looking texture. MISOORA 4-week trial, 30 participants.
07Women over 50 can’t stop talking about it
The serum holds a 4.9-star average across 117 reviews, and it was named an Editor’s Pick by Prime Women, the online magazine for women over 50. Here is what customers say in their own words.
“I’ve been trying so many skincare products, especially now that I’m going through perimenopause and feel like my face is literally melting! But this one has made a HUGE difference for me.”
“My skin feels noticeably more cushioned and hydrated, and the difference in the bounce around my cheeks has been incredible.”
“I absolutely love the MISOORA NAD Firming Serum! I use it every day as part of my skincare routine, and I’m so glad I gave it a try.”
“I really love this serum it makes my face feel so smooth and snatched I recommend it to everyone especially for mature skin.”
How to use itGet the most from every drop
- Morning, after cleansing. Press 2–3 drops into face, neck and jawline. Don’t rub.
- Follow with moisturizer and SPF every day.
- At night, pair it with retinal for a full firming routine.
- Be consistent. Daily use for at least 4 weeks is where the change shows.
Try it yourself
NAD+ Firming Serum, 2,500 ppm
The morning step for mature skin that looks tired and less firm. NAD+, NMN and ATP in a fragrance-free barrier base. Subscribe & Save to never run out.
Shop NAD+ Firming SerumWant the full routine? The sets cost less than the products bought separately.
The 7 reasons at a glance
- It targets tired-looking skin at its source: NAD+ in skin declines with age.1
- The dose is on the label: 2,500 ppm of NAD+.
- NMN and ATP support the whole energy pathway.
- The surprise: zero irritation reported, fragrance-free and ethanol-free.
- A ceramide, cholesterol and linoleic acid base firms without stripping.
- 93% saw firmer-looking skin in 4 weeks.
- A 4.9-star average across 117 reviews.
FAQYour questions, answered
Can I use NAD+ serum with retinal?
Yes. Use NAD+ in the morning and retinal at night. The serum is designed to layer with everything else in the routine, including retinal.
Is it safe for sensitive skin?
It is fragrance-free and ethanol-free, and no irritation was reported in our 4-week trial. As with any new product, patch test first.
How long until I see results?
Many people notice more comfortable, hydrated skin in the first week. In our trial, 93% saw firmer-looking skin at 4 weeks. Results are cosmetic and vary from person to person.
Where should I apply it?
Face, neck and jawline, where thinning and loss of firmness tend to show first. Press it in, don’t rub.
Is a topical NAD+ serum the same as NAD+ supplements?
No. Supplements are taken into the body, while a serum is a cosmetic applied to the skin. A serum makes cosmetic claims only: how your skin looks and feels.
Want the science in more depth? Read why most NAD+ serums do nothing for skin after 50 and our guide to why skin sags after menopause.
References
- Massudi H, Grant R, Braidy N, et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE. 2012;7(7):e42357.
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2021;22:119–141.
- Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Experimental Dermatology. 2000;9(3):165–169.
- Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. The aged epidermal permeability barrier: structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. Journal of Clinical Investigation. 1995;95(5):2281–2290.
Written by MISOORA Editorial. Trial figures come from a MISOORA 4-week consumer trial with 30 participants. This article is for general information and is not medical advice. Product results are cosmetic and vary from person to person.
