Misoora Skincare
PDRN Exosome EGF Night Renewal Serum for Mature Skin
$40.00
Night renewal serum for thin, tired-looking mature skin.
Smoother, bouncier, more even-looking skin, night after night.
Three biotech actives from the world of aesthetic treatments — PDRN, exosomes and EGF — in one gentle evening step, so skin looks denser, smoother and more rested with consistent use.
With age, skin renews more slowly. After menopause it often looks thinner, more fragile and slower to bounce back. Night is when skin does most of its recovery, and this serum is built for that window.
2,000 ppm PDRN, 50 ppm exosomes and 20 ppm EGF — disclosed, not hidden in a blend. Palmitoyl tripeptide-1, 1.5% panthenol and asiaticoside sit in a base of ceramide NP, cholesterol and linoleic acid, so a renewal serum still feels calm on sensitive skin.
- Smoother, denser-looking skin with nightly use
- Softer-looking fine lines, more even-looking tone
- Fragrance-free, alcohol-free, no essential oils
- Pairs with Retinal 0.2%: retinal first, then PDRN
- Face and neck, 1–2 drops every evening
- Contains salmon-derived PDRN (not vegan)
PDRN Exosome EGF Night Renewal Serum for Mature Skin
Night renewal serum for thin, tired-looking mature skin.
Smoother, bouncier, more even-looking skin, night after night.
Three biotech actives from the world of aesthetic treatments — PDRN, exosomes and EGF — in one gentle evening step, so skin looks denser, smoother and more rested with consistent use.
With age, skin renews more slowly. After menopause it often looks thinner, more fragile and slower to bounce back. Night is when skin does most of its recovery, and this serum is built for that window.
2,000 ppm PDRN, 50 ppm exosomes and 20 ppm EGF — disclosed, not hidden in a blend. Palmitoyl tripeptide-1, 1.5% panthenol and asiaticoside sit in a base of ceramide NP, cholesterol and linoleic acid, so a renewal serum still feels calm on sensitive skin.
- Smoother, denser-looking skin with nightly use
- Softer-looking fine lines, more even-looking tone
- Fragrance-free, alcohol-free, no essential oils
- Pairs with Retinal 0.2%: retinal first, then PDRN
- Face and neck, 1–2 drops every evening
- Contains salmon-derived PDRN (not vegan)
Estimated delivery: November 09.
Free US shipping on orders $40+
Renewal that works while you sleep
PDRN, exosomes and EGF are three biotech actives in one night serum. While you sleep, they work on thin, tired-looking skin, so by morning it looks smoother, plumper and more even. Every evening after cleansing, press 2–3 drops into the face and neck, without rubbing.
MISOORA evening routine. Built to work together
Reviews
- JNJessika N.Rated 5 out of 5 stars2 weeks agoGood stuff
like the effect, good for mature skin
- KMKathleen M.Rated 5 out of 5 stars3 weeks agoA lovely addition to my night routine
I wanted something extra for my nighttime skincare, and I really like this serum. My skin feels smoother and more comfortable after using it
- NWNancy W.Rated 5 out of 5 stars3 weeks agoMy skin feels so much better
I’m in my 50s and have been enjoying this in my evening routine. It feels lightweight and leaves my skin soft and hydrated by morning
- CCindyVerified BuyerRated 4 out of 5 stars2 months agoGreat Serum
I am almost finished with my bottle and I've enjoyed using it! I really liked the texture because it wasn't too thick. My skin feels very hydrated.
- NNataliiaVerified BuyerRated 5 out of 5 stars3 months agoMy skin looks smoother and healthier
Great serum! It absorbs quickly, feels amazing on my skin, and I've noticed my skin looks smoother and healthier. I'm very happy with the results and would definitely recommend it.
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PDRN Exosome EGF Night Renewal Serum FAQ
What is the PDRN Exosome EGF Night Renewal Serum?
An evening renewal serum for thin, tired-looking mature skin with 2,000 ppm PDRN, 50 ppm exosomes and 20 ppm EGF. It helps skin look smoother, denser and more even overnight. Size: 30 ml; regular price $40.
What is PDRN, and is it really salmon DNA?
Yes. PDRN (polydeoxyribonucleotide) is made of DNA fragments from salmon and is used in aesthetic clinics for skin renewal and repair. Because it is fish-derived, this serum is not vegan.
What do exosomes and EGF do in skincare?
Exosomes are tiny vesicles that cells use to carry signals to one another. EGF (epidermal growth factor) is a signal protein involved in skin renewal. Together with PDRN they support the look of smoother, plumper, more rested skin.
What else is in the formula?
Palmitoyl tripeptide-1, 1.5% panthenol and asiaticoside, in a barrier base of ceramide NP, cholesterol and linoleic acid, with beta-glucan, bisabolol, allantoin and centella asiatica to keep skin calm. The full ingredient list is on this page.
How do I use the PDRN serum?
Every evening after cleansing, press 2–3 drops into the face and neck without rubbing, then apply moisturizer. If you also use the Retinal 0.2% Barrier Serum, apply retinal first on dry skin, then the PDRN serum, then moisturizer.
Can I use PDRN and retinal together?
Yes, they are designed as one night routine: retinal smooths lines and texture, while PDRN, exosomes and EGF support renewal and comfort. Both come together in the Evening Routine PM Set.
Can I use it after microneedling, laser or a peel?
It is designed for recovery. Wait until acute redness settles, usually 24–48 hours after a procedure, and follow your provider's aftercare advice.
Is it suitable for sensitive skin?
Yes. It is fragrance-free, alcohol-free and contains no essential oils.
How long until I see results?
Skin usually feels calmer and more comfortable in the first week, looks smoother and bouncier in 2–4 weeks, and denser and more even with 8 weeks or more of nightly use. Individual results vary.
Can I use it during pregnancy or breastfeeding?
This formula contains no retinoids. As with any new skincare, check with your doctor before using it during pregnancy or breastfeeding.
Is it tested and cruelty-free?
Yes. The serum is MoCRA registered and FDA listed, cruelty-free, and third-party tested for microbiology, heavy metals and 1,4-dioxane. Certificates of analysis are available on request.
Where can I buy it, and how can I save?
On misoora.com and on Amazon. It is included in the Evening Routine PM Set and the Skin Recharge Set, and Subscribe & Save saves up to 20%.
How much is shipping, and how fast will my order arrive?
Standard shipping is free within the US on orders of $40 or more and on every Subscribe & Save order. Standard delivery takes about 5–7 business days; faster options and international rates are shown at checkout.
What is the return policy?
You can request a return within 30 days of delivery. Email care@misoora.com with your order number, and see our Return Policy for the conditions.
From the Journal
Read before you start
Guides about this product, the routine it belongs to and mature skin in general.
PDRN, Exosomes and EGF: What Biotech Skincare Can and Can't Do for Mature Skin
Salmon DNA, exosomes, growth factors: what each one is, what the evidence actually shows, and where a serum stops and a filler starts.
Read the guide →
Night Sweats, Poor Sleep and Your Skin: A Menopause Night Routine That Helps
Menopause disrupts sleep, and poor sleep shows on skin. What the research says, how to keep nights cooler, and an evening routine built around night sweats.
Read the guide →
Do Collagen Supplements Work After Menopause? What the New Research Says About Your Skin
Collagen powder may help hydration a little, but newer reviews find no reliable effect on wrinkles. Here is what the research says for skin after menopause, and what has a stronger case.
Read the guide →
Our mission
At MISOORA, we believe growing older is a privilege, not a flaw to mask or apologize for. True beauty isn't about chasing unachievable, frozen-in-time standards. It lies in skin resilience and health, and in honoring where you are right now.
Longevity
We wanted every MISOORA product to support you through perimenopause, menopause, and beyond. To guide you on this journey, we made longevity skincare that works as a system, not a collection of disconnected products, formulated to meet the needs of your changing skin.
Transparency
We believe you deserve total honesty. MISOORA discloses exact active concentrations and 100% clean ingredients, fully verified by MoCRA registration, FDA listing, and third-party testing. So you can feel completely confident in gentle, barrier-friendly formulas built to honor, protect, and support your skin as you age.
Safety
Always the best and safest ingredients out there. Because MISOORA focuses on nourishing your skin rather than harsh chemical exfoliation, every formula is delightfully gentle, ethanol-free, and suitable for all skin types, including sensitive. Created for the unique, evolving needs of skin in your 50s, 60s, 70s, and beyond.
Science
All our products are formulated with the best ingredient selection and carefully tested specifically for mature skin needs:
NAD+ → To recharge aging skin cells.
PDRN → To refine texture.
Exosomes → To boost firmness.
EGF → To stimulate natural collagen.
Retinaldehyde → To soften wrinkles.
Ceramides → To rebuild the barrier.
Centella → To reduce irritation.
A welcome gift from MISOORA
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- ✓Smoother, bouncier-looking skin by morning
- ✓2,000 ppm PDRN, plus exosomes and EGF
- ✓Gentle enough for nightly use, right after retinal
Best forThin-looking skinTextureEvening
- Free US shipping on orders $40+
- Easy 30-day returns
- Fragrance-free formula
- Third-party safety tested
Better as a set
Evening Routine PM Set
Includes this plus Centella Cleanser, Retinal 0.2% and Ceramide+ Moisturizer.
$78$104Save $26